Microenvironmental markers are correlated with lymph node metastasis in invasive submucosal colorectal cancer.

Tamotsu SugaiNoriyuki YamadaMitsumasa OsakabeMai HashimotoNoriyuki UesugiMakoto EizukaYoshihito TanakaRyo SugimotoNaoki YanagawaTakayuki Matsumoto

Published in: Histopathology (2021)

Our findings showed that expression patterns of cancer cell- and CAF-related proteins may allow for stratification of patients into risk categories for LNM in SiCRC. In addition, Ki-67- and FAP-1-expressing microenvironmental cells might be helpful for identification of correlations with LNM in SiCRC.

Keyphrases

lymph node metastasis
end stage renal disease
induced apoptosis
squamous cell carcinoma
newly diagnosed
ejection fraction
prognostic factors
cell cycle arrest
patient reported outcomes
neoadjuvant chemotherapy
cell death
signaling pathway
endoplasmic reticulum stress
rectal cancer
long non coding rna