ESBL-producing strains isolated from imported cases of enteric fever in England and Wales reveal multiple chromosomal integrations of blaCTX-M-15 in XDR Salmonella Typhi.

Satheesh NairMarie ChattawayGemma C LangridgeAmy GentleMartin DayEmma V AinsworthIman MohamedRobert SmithClaire JenkinsTimothy J DallmanGauri Godbole

Published in: The Journal of antimicrobial chemotherapy (2021)

Chromosomal integration of blaCTX-M-15 within the XDR Sindh strains may lead to the maintenance of resistance in the absence of antibiotic selection pressure. Empirical treatment of cases of complicated enteric fever returning from Pakistan will henceforth have to include a carbapenem.

Keyphrases

escherichia coli
klebsiella pneumoniae
drug resistant
multidrug resistant
copy number
acinetobacter baumannii
genome wide
gram negative
single cell
tertiary care
combination therapy
pseudomonas aeruginosa
listeria monocytogenes
replacement therapy