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MaxSynBio: Avenues Towards Creating Cells from the Bottom Up.

Petra SchwilleJoachim SpatzKatharina LandfesterEberhard BodenschatzStephan HerminghausVictor SourjikTobias J ErbPhilippe BastiaensReinhard LipowskyAnthony HymanPeter DabrockJean-Christophe BaretTanja Vidakovic-KochPeter BielingRumiana DimovaHannes MutschlerTom RobinsonT-Y Dora TangSeraphine WegnerKai Sundmacher
Published in: Angewandte Chemie (International ed. in English) (2018)
A large German research consortium mainly within the Max Planck Society ("MaxSynBio") was formed to investigate living systems from a fundamental perspective. The research program of MaxSynBio relies solely on the bottom-up approach to synthetic biology. MaxSynBio focuses on the detailed analysis and understanding of essential processes of life through modular reconstitution in minimal synthetic systems. The ultimate goal is to construct a basic living unit entirely from non-living components. The fundamental insights gained from the activities in MaxSynBio could eventually be utilized for establishing a new generation of biotechnological processes, which would be based on synthetic cell constructs that replace the natural cells currently used in conventional biotechnology.
Keyphrases
  • induced apoptosis
  • quality improvement
  • cell cycle arrest
  • stem cells
  • cell therapy
  • oxidative stress
  • cell proliferation
  • data analysis