Massive weight loss following deep brain stimulation of the nucleus accumbens in a depressed woman.
Volker M TronnierDirk RascheVeronika ThornsDaniel Alvarez-FischerThomas F MünteBartosz ZurowskiPublished in: Neurocase (2018)
Obese individuals share behavioral characteristics with drug/alcohol addicts as well as obsessive compulsive disease. Deep brain stimulation (DBS) has been used successfully in these disorders, thus warranting an evaluation in obesity. A woman with treatment-resistant depression as well as severe obesity was selected for DBS of the nucleus accumbens (NAcc) bilaterally with depression being the primary and obesity being the secondary target of treatment. Compared to earlier bariatric surgery, the patient showed accelerated weight loss after DBS. Also, depression was significantly reduced. The current case suggests that DBS of the NAcc warrants further evaluation in patients unresponsive to other treatments.
Keyphrases
- deep brain stimulation
- weight loss
- bariatric surgery
- obsessive compulsive disorder
- parkinson disease
- roux en y gastric bypass
- gastric bypass
- obese patients
- depressive symptoms
- sleep quality
- end stage renal disease
- case report
- weight gain
- glycemic control
- newly diagnosed
- ejection fraction
- metabolic syndrome
- prognostic factors
- insulin resistance
- emergency department
- peritoneal dialysis
- type diabetes
- physical activity
- early onset
- high fat diet induced
- combination therapy
- body mass index
- adipose tissue
- skeletal muscle
- patient reported outcomes
- patient reported