Agathisflavone: Botanical sources, therapeutic promises, and molecular docking study.
Muhammad Torequl IslamS M Neamul Kabir ZihadMd Shamim RahmanNazifa SifatMd Roich KhanShaikh Jamal UddinRazina RoufPublished in: IUBMB life (2019)
In this article, we have summarized the biological sources and pharmacological activities of agathisflavone along with molecular docking studies to correlate the interaction of this biflavonoid and biomacromolecules involving in its biological effects observed in database-oriented scientific reports. For this, an up-to-date (from 1991 to October 2018) search was done on the databases such as PubMed, Science Direct, Web of Science, Scopus, The American Chemical Society, Clinicaltrials.gov, and Google Scholar databases. The findings suggest that agathisflavone possesses antioxidant, anti-inflammatory, antiviral, antiparasitic, cytotoxic, neuroprotective, and hepatoprotective activities. An in silico study of agathisflavone against 17 essential proteins/enzymes revealed that inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 are the most efficient enzymes for the interaction and binding of this biflavonoid for its anti-inflammatory activity. In conclusion, agathisflavone may be one of the promising plant-derived lead compounds in the treatment of oxidative stress, inflammatory diseases, microbial infection, hepatic and neurological diseases and disorders, and cancer. © 2019 IUBMB Life, 71(9):1192-1200, 2019.
Keyphrases
- molecular docking
- nitric oxide synthase
- oxidative stress
- molecular dynamics simulations
- anti inflammatory
- nitric oxide
- public health
- drinking water
- big data
- squamous cell carcinoma
- microbial community
- emergency department
- machine learning
- diabetic rats
- artificial intelligence
- combination therapy
- single cell
- squamous cell
- endoplasmic reticulum stress
- induced apoptosis
- blood brain barrier
- heat stress