The usefulness of MMP-9, TIMP-1 and MMP-9/TIMP-1 ratio for diagnosis and assessment of COPD severity.
Sanja Dimic-JanjicMir Alireza HodaBranislava MilenkovicJelena Kotur-StevuljevicMihailo StjepanovicDaniela GompelmannJelena JankovicMilica MiljkovicJelena Milin-LazovicNatasa DjurdjevicDragana MaricIvan MilivojevicSpasoje PopevicPublished in: European journal of medical research (2023)
COPD patients have elevated serum levels of MMP-9 and TIMP-1 and MMP-9/TIMP-1 ratio. COPD patients have an imbalance between MMP-9 and TIMP-1 in favor of a pro-proteolytic environment, which overall indicates the importance of the MMP-9/TIMP-1 ratio as a potential biomarker for COPD diagnosis and severity.