Do exosomes play role in cardiovascular disease development in hematological malignancy?
Fatemeh Javaherforoosh ZadehYasmin GhasemiSaeede BagheriMohsen MalekniaNader DavariHadi RezaeeyanPublished in: Molecular biology reports (2020)
Exosomes play a role in the pathogenesis and treatment of malignancies as a double-edged sword. Recently, researchers discussed about two new roles, cardiomyocyte function impairment and cardiovascular disease (CVD) genesis. Data were collected from PUBMED at various time points up to the 2019 academic year. The related key words are listed as following; "Arsenic trioxide", "acute promyelocytic leukemia" and "cardio toxicity" and "molecular pathway" and "biomarker". This study has shown that exosomes secreted substances stimulate angiogenesis and cardiomyocytes repairment; cited process depended on the kinds of released substances. Generally, exosomes may involve in the pathogenesis of CVD; although CVD can prevented by identifying the pathways that induce angiogenesis.
Keyphrases
- cardiovascular disease
- mesenchymal stem cells
- stem cells
- drinking water
- endothelial cells
- bone marrow
- vascular endothelial growth factor
- liver failure
- oxidative stress
- electronic health record
- wound healing
- drug induced
- cardiovascular risk factors
- metabolic syndrome
- heavy metals
- cardiovascular events
- single molecule
- high glucose
- intensive care unit
- combination therapy
- replacement therapy