Role of R-spondin 2 in arterial lymphangiogenesis and atherosclerosis.

Bhupesh Singla Hui-Ping Lin Alex Chen WonMo AhnPushpankur GhoshalMary Cherian-ShawJoseph WhiteBrian K StansfieldGábor Csányi

Published in: Cardiovascular research (2022)

These findings demonstrate that RSPO2 inhibits lymphangiogenesis via LGR4 and downstream impairment of AKT-eNOS-nitric oxide signalling. These results may also inform new therapeutic strategies to promote lymphangiogenesis and improve cholesterol efflux from atherosclerotic arteries.

Keyphrases

nitric oxide
nitric oxide synthase
signaling pathway
cell proliferation
cardiovascular disease
endothelial cells
pi k akt
hydrogen peroxide
type diabetes