CircMYH9 drives colorectal cancer growth by regulating serine metabolism and redox homeostasis in a p53-dependent manner.

Xin LiuYunze LiuZhao LiuChangwei LinFanchao MengLei XuXiuzhong ZhangChong ZhangPenbo ZhangShuai GongNai WuZeqiang RenJun SongYi Zhang

Published in: Molecular cancer (2021)

The overexpression of circMYH9 promotes CRC proliferation though modulating serine/glycine metabolism and redox homeostasis in a p53-dependent manner, and targeting circMYH9 and its pathway may be an effective strategy for the treatment of CRC.

Keyphrases

signaling pathway
protein kinase
cell proliferation
transcription factor
cancer therapy
combination therapy
drug delivery