Engineering Dynamic Defect of Ce III /Ce IV -Based Metal-Organic Framework through Ultrasound-Triggered Au Electron Trapper for Sonodynamic Therapy of Osteomyelitis.
Qiyao ZhengXiangmei LiuSong GaoZhenduo CuiShui-Lin WuYanqin LiangZhaoyang LiYufeng ZhengShengli ZhuHui JiangRuqiang ZouPublished in: Small (Weinheim an der Bergstrasse, Germany) (2023)
Defect engineering is an important way to tune the catalytic properties of metal-organic framework (MOF), yet precise control of defects is difficult to achieve. Herein, a cerium-based MOF (CeTCPP) is decorated with Au nanoparticles. Under ultrasound irradiation, Au nanoparticles can precisely turn 1/3 of the pristine Ce 3+ nodes into Ce 4+ . With the stable existence of Ce 4+ , the coordination of Ce nodes changed, causing the structural irregularity in CeTCPP-Au, so that the electron-hole recombination is obviously hindered, facilitating the generation of reactive oxygen species. Therefore, under 20 min of ultrasound irradiation, the CeTCPP-Au showed superior antibacterial efficacy of over 99% against Staphylococcus aureus and Escherichia coli with good biocompatibility, which is further used for effective therapy of osteomyelitis. Overall, this work provides a dynamic defect formation strategy of MOF through the electron trapping of Au nanoparticles, which also sheds light on sonodynamic therapy in curing deep-seated lesions.
Keyphrases
- metal organic framework
- sensitive detection
- reduced graphene oxide
- energy transfer
- staphylococcus aureus
- quantum dots
- magnetic resonance imaging
- escherichia coli
- reactive oxygen species
- gold nanoparticles
- visible light
- sentinel lymph node
- squamous cell carcinoma
- oxidative stress
- ultrasound guided
- biofilm formation
- radiation induced
- contrast enhanced ultrasound
- anti inflammatory
- dna repair
- candida albicans
- silver nanoparticles
- methicillin resistant staphylococcus aureus
- mesenchymal stem cells