Urolithin A improves Alzheimer's disease cognition and restores mitophagy and lysosomal functions.

Yujun HouXixia ChuJae-Hyeon ParkQing ZhuMansoor HussainZhiquan LiHelena Borland MadsenBeimeng YangYong WeiYue WangEvandro F FangDeborah L CroteauVilhelm A Bohr

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)

Long-term urolithin A (UA) treatment improved learning, memory, and olfactory function in Alzheimer's disease (AD) mice. UA restored lysosomal functions in part by regulating cathepsin Z (Ctsz) protein. UA modulates immune responses and AD-specific pathophysiological pathways.

Keyphrases

immune response
cognitive decline
working memory
toll like receptor
type diabetes
dendritic cells
high fat diet induced
white matter
inflammatory response
combination therapy
small molecule