Combined transplantation of hiPSC-NSC and hMSC ameliorated neuroinflammation and promoted neuroregeneration in acute spinal cord injury.
Xiaofeng DuDesheng KongRuiyun GuoBoxin LiuJingjing HeJinyu ZhangAsiamah Ernest AmponsahHuixian CuiJun MaPublished in: Stem cell research & therapy (2024)
Combined transplantation of hiPSC-NSC and hMSC could significantly ameliorate neuroinflammation, promote neuroregeneration, and decrease spinal fibrosis degree in safe and effective pattern, which would be indicated as a novel potential cell treatment option.
Keyphrases
- spinal cord injury
- cell therapy
- spinal cord
- lipopolysaccharide induced
- traumatic brain injury
- lps induced
- liver failure
- cognitive impairment
- single cell
- cerebral ischemia
- inflammatory response
- neuropathic pain
- stem cells
- mesenchymal stem cells
- risk assessment
- combination therapy
- acute respiratory distress syndrome
- climate change
- liver fibrosis
- replacement therapy