Anti-inflammatory effects of infliximab and methotrexate on peripheral blood and synovial fluid mononuclear cells: ex vivo study.
Smadar GertelM RokachAri PolachekI LitinskyM AnoukOri ElkayamVictoria FurerPublished in: Scandinavian journal of rheumatology (2024)
Both IFX and MTX effectively inhibited PBMC proliferation and IFN-γ production, but only IFX reduced synovial monocytes and pro-inflammatory gene expression in SFMCs, suggesting a differential impact of IFX and MTX on critical inflammatory cell populations ex vivo.
Keyphrases
- peripheral blood
- gene expression
- induced apoptosis
- dna methylation
- dendritic cells
- cell cycle arrest
- signaling pathway
- single cell
- oxidative stress
- immune response
- cell therapy
- high dose
- endoplasmic reticulum stress
- stem cells
- low dose
- cell death
- ulcerative colitis
- mesenchymal stem cells
- cell proliferation
- genetic diversity