Recent Developments in Zn-Based Biodegradable Materials for Biomedical Applications.
Muzamil HussainSami UllahMuhammad Rafi RazaNaseem AbbasAhsan AliPublished in: Journal of functional biomaterials (2022)
Zn-based biodegradable alloys or composites have the potential to be developed to next-generation orthopedic implants as alternatives to conventional implants to avoid revision surgeries and to reduce biocompatibility issues. This review summarizes the current research status on Zn-based biodegradable materials. The biological function of Zn, design criteria for orthopedic implants, and corrosion behavior of biodegradable materials are briefly discussed. The performance of many novel zinc-based biodegradable materials is evaluated in terms of biodegradation, biocompatibility, and mechanical properties. Zn-based materials perform a significant role in bone metabolism and the growth of new cells and show medium degradation without the release of excessive hydrogen. The addition of alloying elements such as Mg, Zr, Mn, Ca, and Li into pure Zn enhances the mechanical properties of Zn alloys. Grain refinement by the application of post-processing techniques is effective for the development of many suitable Zn-based biodegradable materials.
Keyphrases
- heavy metals
- drug delivery
- induced apoptosis
- soft tissue
- total knee arthroplasty
- computed tomography
- gold nanoparticles
- oxidative stress
- cell proliferation
- endoplasmic reticulum stress
- ionic liquid
- metal organic framework
- pet ct
- pi k akt
- total hip arthroplasty
- oxide nanoparticles
- reduced graphene oxide
- visible light