PP4 inhibition sensitizes ovarian cancer to NK cell-mediated cytotoxicity via STAT1 activation and inflammatory signaling.

Remya RajaChristopher WuEsen Yonca BassoyThomas E RubinoEmma C UtagawaPaul M MagtibayKristina A ButlerMarion Curtis

Published in: Journal for immunotherapy of cancer (2022)

Our work has identified a role for PP4 inhibition in promoting inflammatory signaling and enhanced immune cell effector function. These findings support the further investigation of PP4 inhibitors to enhance chemo-immunotherapy for OC treatment.

Keyphrases

nk cells
oxidative stress
photodynamic therapy
combination therapy
dendritic cells
regulatory t cells
squamous cell carcinoma
locally advanced
signaling pathway
immune response
drug delivery
radiation therapy
replacement therapy