The relationship between circulating lipids and breast cancer risk: A Mendelian randomization study.
Kelsey E JohnsonKatherine M SiewertDerek M KlarinScott M Damrauernull nullKyong-Mi ChangPhilip S TsaoThemistocles L AssimesKara N MaxwellBenjamin F VoightPublished in: PLoS medicine (2020)
We observed that genetically elevated plasma HDL and LDL levels appear to be associated with increased BC risk. Future studies are required to understand the mechanism underlying this putative causal relationship, with the goal of developing potential therapeutic strategies aimed at altering the cholesterol-mediated effect on BC risk.