E2F1 Mediates SOX17 Deficiency-Induced Pulmonary Hypertension.
Dan YiBin LiuHongxu DingShuai LiRebecca LiJiakai PanKarina RamirezXiaomei XiaMrinalini KalaIndrapal SinghQinmao YeWon Hee LeeRichard E FryeTing WangYutong ZhaoKenneth S KnoxChristopher C GlembotskiMichael B FallonZhiyu DaiPublished in: bioRxiv : the preprint server for biology (2023)
Our study demonstrated that endothelial SOX17 deficiency induces PH through E2F1 and targeting E2F1 signaling represents a promising approach in PAH patients.
Keyphrases
- pulmonary hypertension
- end stage renal disease
- stem cells
- transcription factor
- ejection fraction
- newly diagnosed
- chronic kidney disease
- high glucose
- endothelial cells
- peritoneal dialysis
- prognostic factors
- pulmonary artery
- diabetic rats
- pulmonary arterial hypertension
- patient reported outcomes
- oxidative stress
- drug induced
- stress induced