The impact of improved detection and treatment of isoniazid resistant tuberculosis on prevalence of multi-drug resistant tuberculosis: A modelling study.

Kamila RomanowskiJonathon R CampbellOlivia OxladeFederica FregoneseDick MenziesJames C Johnston

Published in: PloS one (2019)

Accurate diagnosis and tailored treatment of INHR-TB with LPA led to an almost 50% relative decrease in acquired MDR-TB when compared with an Xpert MTB/RIF strategy. Continued reliance on diagnostic and treatment protocols that ignore INHR-TB will likely result in further generation of MDR-TB.

Keyphrases

mycobacterium tuberculosis
drug resistant
multidrug resistant
pulmonary tuberculosis
emergency department
hiv aids
risk factors
acinetobacter baumannii
combination therapy
smoking cessation