Targeting DCLK1 overcomes 5-fluorouracil resistance in colorectal cancer through inhibiting CCAR1/β-catenin pathway-mediated cancer stemness.

Lanqing WangLei ZhaoZhenyu LinDandan YuMin JinPengfei ZhouJinghua RenJing ChengKunyu YangGang WuTao ZhangDejun Zhang

Published in: Clinical and translational medicine (2022)

Collectively, our findings reveal that DCLK1 promotes 5-fluorouracil resistance in CRC by CCAR1/β-catenin pathway-mediated cancer stemness, and suggest that targeting DCLK1 might be a promising method to eliminate cancer stem cells for overcoming 5-fluorouracil resistance in CRC.

Keyphrases

cancer stem cells
papillary thyroid
stem cells
squamous cell
epithelial mesenchymal transition
cancer therapy
lymph node metastasis
gene expression
young adults
dna methylation