Age at onset prediction in spinocerebellar ataxia type 3 changes according to population of origin.
E P de MattosV B LeottiB-W SoongM RaposoM LimaJ VasconcelosH FussigerG N SouzaN KerstingG V FurtadoJ A M SauteS A CameyMaria-Luiza Saraiva-PereiraL B JardimPublished in: European journal of neurology (2018)
Our data strongly support the existence of as yet unknown factors that modulate AO in SCA3/MJD in a population-dependent manner, independent of CAG expansion length. The generated models are made available to the scientific community as they can be useful for future studies on SCA3/MJD carriers from distinct geographical origins.