Fabrication and Characterization of Antifungal Hydroxypropyl-β-Cyclodextrin/Pyrimethanil Inclusion Compound Nanofibers Based on Electrospinning.
Shuang GaoWeiwei FengHan SunLei ZongXiaoming LiLixia ZhaoFei YeYing FuPublished in: Journal of agricultural and food chemistry (2022)
Pyrimethanil (PMT) is an anilinopyrimidine bactericide with poor water solubility, which limits its applications. To improve the physical and chemical properties of PMT, hydroxypropyl-β-cyclodextrin/pyrimethanil inclusion compound nanofibers (HPβCD/PMT-IC-NFs) were fabricated via electrospinning. A variety of analytical techniques were used to confirm the formation of the inclusion compound. Scanning electron microscopy image displayed that HPβCD/PMT-IC-NF was homogeneous without particles. Thermogravimetric analysis indicated that the formation of the inclusion compound improved the thermostability of PMT. In addition, the phase solubility test illustrated that the inclusion compound formed by PMT and HPβCD had a stronger water solubility. The antifungal effect test exhibited that HPβCD/PMT-IC-NF had better antifungal properties. The release experiment confirmed that HPβCD/PMT-IC-NF had a sustained-release effect, and the release curve conformed to the first-order kinetic model equation. In short, the fabrication HPβCD/PMT-IC-NF inhibited improved solubility and thermostability of PMT, thus promoting the development of pesticide dosage form to water-based and low-pollution direction.
Keyphrases
- signaling pathway
- lps induced
- oxidative stress
- nk cells
- electron microscopy
- candida albicans
- risk assessment
- pi k akt
- nuclear factor
- physical activity
- deep learning
- high resolution
- mass spectrometry
- heavy metals
- immune response
- inflammatory response
- cell proliferation
- toll like receptor
- low cost
- human health
- health risk assessment