Cytoplasmic HDAC4 regulates the membrane repair mechanism in Duchenne muscular dystrophy.
Alessandra RenziniNicoletta MarroncelliGiorgia CavioliSilvia Di FrancescantonioLaura ForcinaAlessandro LambridisEros Di GiorgioSergio ValenteAntonello MaiClaudio BrancoliniClaudia GiampietriAlessandra MagentaFrancesca De SantaSergio AdamoDario ColettiViviana MoresiPublished in: Journal of cachexia, sarcopenia and muscle (2022)
Histone deacetylase 4 performs crucial functions in the cytoplasm of dystrophic muscles, by mediating the muscle repair response to damage, an important role in ensuring muscle homeostasis, probably by stabilizing Trim72 mRNA. Consequently, the cytoplasmic functions of HDAC4 should be stimulated rather than inhibited in muscular dystrophy treatments, a fact to be considered in future therapeutic approaches.