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Progress toward the Total Synthesis of Nogalamycin Using a Benzyne Cycloaddition Strategy.

Hillary J DequinaLogan E VineJoseph T RobeyWilliam T RaskopfJennifer M Schomaker
Published in: The Journal of organic chemistry (2024)
Nogalamycin (NOG) is a member of the anthracycline glycoside natural products; no total syntheses have yet been reported, and there is minimal understanding of how the aglycone substitution pattern and identities of the A- and D-ring sugars impact the anticancer activity and toxicity. This paper reports progress toward a modular approach to NOG that could enable systematic structure-activity relationship studies. Key steps include a regioselective benzyne cycloaddition and reductive ring-opening to assemble a versatile AB core for analogue synthesis.
Keyphrases
  • structure activity relationship
  • oxidative stress
  • case control
  • adverse drug
  • emergency department
  • oxide nanoparticles