Novel role of MHC class II transactivator in hepatitis B virus replication and viral counteraction.
Mehrangiz DezhbordSeong Ho KimSoree ParkDa Rae LeeNayeon KimJuhee WonAh Ram LeeDong-Sik KimKyun-Hwan Kim
Published in: Clinical and molecular hepatology (2024)
Our findings reveal a novel antiviral mechanism of CIITA that involves the modulation of the ERK pathway to restrict HBV transcription. Additionally, our results suggest the possibility of a new immune avoidance mechanism involving HBx.