Copper-Catalyzed, Regioselective, Unsymmetrical Homocoupling of Quinoxalin-2(1 H )-ones to Form C-N Homodimers.

An environmentally benign and efficient method for the synthesis of unsymmetrical diquinoxalin-2(1 H )-ones with potential axial chirality via inexpensive copper-catalyzed, low-toxicity, and stable PIFA oxidation, rarely assisted by PhSeSePh, regioselective homocoupling of quinoxalin-2(1 H )-ones under mild conditions is developed. This practical scheme is compatible with a variety of functional groups and allows the preparation of functionalized unsymmetrical dimeric quinoxalin-2(1 H )-ones from readily available and safe starting materials, providing new ideas for the sustainable development of methodological studies of quinoxalin-2(1 H )-ones.