Inhibition of Endothelial PHD2 Suppresses Post-Ischemic Kidney Inflammation through Hypoxia-Inducible Factor-1.
Ganeshkumar RajendranMichael P SchonfeldRatnakar TiwariShengping HuangRafael TorosyanTimothy FieldsJiwhan ParkKatalin SusztákPinelopi P KapitsinouPublished in: Journal of the American Society of Nephrology : JASN (2020)
Our findings suggest that activation of endothelial HIF-1 signaling through PHD2 inhibition may offer a novel therapeutic approach against ischemic AKI.