Allogenic stem cell transplant-associated acute graft versus host disease: a computational drug discovery text mining approach using oral and gut microbiome signatures.
M F BeckmanD S MortonJean-Luc C MougeotJ-L C MougeotPublished in: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer (2020)
Reduced microbial diversity reflects higher severity and mortality rate in HSCT patients with aGVHD. Multi-omics approaches to decipher oral and gut microbiome associations will be critical for developing aGVHD preventive therapies.
Keyphrases
- drug discovery
- stem cells
- liver failure
- respiratory failure
- microbial community
- single cell
- cardiovascular events
- genome wide
- risk factors
- smoking cessation
- cardiovascular disease
- type diabetes
- dna methylation
- aortic dissection
- gene expression
- mesenchymal stem cells
- cell therapy
- bone marrow
- acute respiratory distress syndrome