Profiling of Unfolded Protein Response Markers and Effect of IRE1α-specific Inhibitor in Pituitary Neuroendocrine Tumor.

Shuhei Morita Shinsuke UrakiHiroyuki AriyasuTomoya TsujiAsako DoiHiroto FurutaToshikazu YamotoNaoyuki NakaoTakashi AkamizuTaka-Aki Matsuoka

Published in: Endocrinology (2024)

UPR markers in FPitNETs are implicated as dominant A-UPR but blunted T-UPR. KIRA8, enhanced with octreotide, unbalances the UPR, leading to antitumor effects. Targeting IRE1α may provide a novel strategy to treat PitNETs.

Keyphrases

endoplasmic reticulum stress
binding protein
small molecule
drug delivery
growth hormone