The effects of necrostatin-1 on the in vitro development and function of young porcine islets over 14-day prolonged tissue culture.
Hien LauNicole CorralesSamuel RodriguezSoomin ParkMohammadreza MohammadiShiri LiMichael AlexanderJonathan R T LakeyPublished in: Xenotransplantation (2021)
The growth-inducing effects of Nec-1 on PPIs were most effective on day 7 of tissue culture when added on day 3. Our findings support existing evidence that the in vitro activities of Nec-1 are short-lived and encourage future studies to explore the use of other novel growth factors during prolonged islet tissue culture.
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