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Skin deep: The decoupling of genetic admixture levels from phenotypes that differed between source populations.

Jaehee KimMichael D EdgeAmy GoldbergNoah A Rosenberg
Published in: American journal of physical anthropology (2021)
The mechanistic framework suggests that in an admixed population, a trait that initially differed between source populations might serve as a reliable proxy for ancestry for only a short time, especially if the trait is determined by few loci. It follows that a social categorization based on such a trait is increasingly uninformative about genetic ancestry and about other traits that differed between source populations at the onset of admixture.
Keyphrases
  • genome wide
  • dna methylation
  • copy number
  • genome wide association study
  • healthcare
  • gene expression
  • soft tissue