Treatment of progressive multiple sclerosis with high-dose all-trans retinoic acid - no clear evidence of positive disease modifying effects.
Christoph RuschilEvelyn DuboisMaria-Ioanna StefanouMarkus Christian KowarikUlf ZiemannMarcus SchittenhelmMarkus KrumbholzFelix BischofPublished in: Neurological research and practice (2021)
Stand-alone therapy with ATRA did not ameliorate progressive MS in our limited cohort and we did not observe consistent alterations of T and B cell subsets. Intriguingly, application of ATRA may have caused marked disease exacerbation in one patient.