A Confirmed Case of SARS-CoV-2 Pneumonia With Negative Routine Reverse Transcriptase-Polymerase Chain Reaction and Virus Variation in Guangzhou, China.

Zhengtu LiYinhu LiLingdan ChenShaoqiang LiLe YuAiru ZhuFeng YangQian JiangLiyan ChenJincun ZhaoWenju LuNanshan ZhongZheng-Tu Li

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)

This case highlighted that false-negative results could be present in routine RT-PCR diagnosis, especially with virus variation. Currently, nanopore pathogen sequencing and antibody detection have been found to be effective in clinical diagnosis.

Keyphrases

sars cov
clinical practice
real time pcr
single molecule
single cell
candida albicans
label free
community acquired pneumonia
mechanical ventilation
sensitive detection