Association of Plasma YKL-40 With MRI, CSF, and Cognitive Markers of Brain Health and Dementia.
Matthew P PaseJayanadra J HimaliRaquel PuertaAlexa S BeiserMitzi M GonzalesClaudia L SatizabalQiong YangHugo Javier AparicioDaniel J KojisCharles S DecarliOscar L LopezWill LongstrethVilmundur G GudnasonThomas H MosleyJoshua C BisAlison E FohnerBruce M PsatyMerce BoadaPablo García-GonzálezSergi ValeroMarta MarquiéRussell TracyLenore J LaunerAgustin RuizMyriam FornageSudha SeshadriPublished in: Neurology (2024)
Higher plasma YKL-40 levels were associated with lower brain volume, poorer cognition, and incident dementia. Plasma YKL-40 may be useful for studying the association of inflammation and its treatment on dementia risk.