Anti-Cytokine Therapy to Attenuate Ischemic-Reperfusion Associated Brain Injury in the Perinatal Period.
Clémence DisdierXiaodi ChenJeong-Eun KimSteven W ThrelkeldBarbara S StonestreetPublished in: Brain sciences (2018)
Perinatal brain injury is a major cause of morbidity and long-standing disability in newborns. Hypothermia is the only therapy approved to attenuate brain injury in the newborn. However, this treatment is unfortunately only partially neuroprotective and can only be used to treat hypoxic-ischemic encephalopathy in full term infants. Therefore, there is an urgent need for adjunctive therapeutic strategies. Post-ischemic neuro-inflammation is a crucial contributor to the evolution of brain injury in neonates and constitutes a promising therapeutic target. Recently, we demonstrated encouraging neuroprotective capacities of anti-cytokine monoclonal antibodies (mAbs) in an ischemic-reperfusion (I/R) model of brain injury in the ovine fetus. The purpose of this review is to summarize the current knowledge regarding the inflammatory response in the perinatal sheep brain after I/R injury and to review our recent findings regarding the beneficial effects of treatment with anti-cytokine mAbs.
Keyphrases
- brain injury
- cerebral ischemia
- subarachnoid hemorrhage
- pregnant women
- inflammatory response
- healthcare
- stem cells
- early onset
- heart failure
- low birth weight
- white matter
- lipopolysaccharide induced
- gestational age
- coronary artery disease
- acute coronary syndrome
- cardiac arrest
- acute myocardial infarction
- acute ischemic stroke
- functional connectivity
- toll like receptor
- resting state
- bone marrow
- preterm birth