A nanowire-based liquid biopsy method using cerebrospinal fluid cell-free DNA for targeted management of leptomeningeal carcinomatosis.
Wonyoung ChoiYoungnam ChoSeog-Yun ParkKum Hui HwangJi-Youn HanYoung Joo LeePublished in: Journal of cancer research and clinical oncology (2020)
Genotyping CSF-cfDNA by the nanowire-based assay is feasible and effective in guiding the treatment of LMC in patients with EGFR-mutant NSCLC.
Keyphrases
- cerebrospinal fluid
- small cell lung cancer
- room temperature
- high throughput
- epidermal growth factor receptor
- tyrosine kinase
- brain metastases
- genome wide
- advanced non small cell lung cancer
- cancer therapy
- ultrasound guided
- gene expression
- single cell
- drug delivery
- fine needle aspiration
- combination therapy
- high density