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Pleiotropic effect of the ABCG2 gene in gout: involvement in serum urate levels and progression from hyperuricemia to gout.

Rebekah WrigleyAmanda J Phipps-GreenRuth K ToplessTanya J MajorMurray CadzowPhilip RichesAnne-Kathrin TauscheMatthijs JanssenLeo A B JoostenTim L JansenAlexander SoJennie Harré HindmarshLisa K StampNicola DalbethTony Raymond Merriman
Published in: Arthritis research & therapy (2020)
These data are consistent with a role for ABCG2 141K in gout in the presence of established HU.
Keyphrases
  • uric acid
  • metabolic syndrome
  • electronic health record
  • genome wide
  • copy number
  • big data
  • gene expression
  • machine learning
  • cancer stem cells
  • dna methylation
  • transcription factor
  • deep learning
  • genome wide analysis