Pleiotropic effect of the ABCG2 gene in gout: involvement in serum urate levels and progression from hyperuricemia to gout.

Rebekah WrigleyAmanda J Phipps-GreenRuth K ToplessTanya J MajorMurray CadzowPhilip RichesAnne-Kathrin TauscheMatthijs JanssenLeo A B JoostenTim L JansenAlexander SoJennie Harré HindmarshLisa K StampNicola DalbethTony Raymond Merriman

Published in: Arthritis research & therapy (2020)

These data are consistent with a role for ABCG2 141K in gout in the presence of established HU.

Keyphrases

uric acid
metabolic syndrome
electronic health record
genome wide

copy number
big data
gene expression

machine learning
cancer stem cells
dna methylation

transcription factor
deep learning
genome wide analysis