Cardiomyocyte PANX1 Controls Glycolysis and Neutrophil Recruitment in Hypertrophy.
Caitlin M PavelecAlexander P YoungHannah L LuvianoEmily E OrrellAnna SzagdajNabin PoudelAbigail G WolpeSamantha H ThomasScott YeudallClint M UpchurchMark D OkusaBrant E IsaksonMatthew J WolfNorbert LeitingerPublished in: Circulation research (2024)
Together, these data demonstrate that PANX1 deficiency in cardiomyocytes increases glycolytic metabolism and protects against cardiac hypertrophy in nonischemic heart failure at least in part by reducing immune cell recruitment. Our study implies PANX1 channel inhibition as a therapeutic approach to ameliorate cardiac dysfunction in patients with heart failure.