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AMYCO: evaluation of mutational impact on prion-like proteins aggregation propensity.

Valentin IglesiasOscar Conchillo-SoleCristina BatlleSalvador Ventura
Published in: BMC bioinformatics (2019)
The AMYCO web server allows for a fast and automated evaluation of the effect of mutations on the aggregation properties of prion-like proteins. This might uncover novel disease-linked amino acid changes in the sequences of human prion-like proteins. Additionally, it can find application in the in silico design of synthetic prion-like proteins with tuned aggregation propensities for different purposes. AMYCO does not require previous registration and is freely available to all users at: http://bioinf.uab.cat/amyco/ .
Keyphrases
  • amino acid
  • endothelial cells
  • machine learning
  • deep learning
  • high throughput
  • molecular docking
  • induced pluripotent stem cells
  • small molecule