Effects of ethanol on mechanical allodynia and dynamic weight bearing in male and female mice with spared nerve injury.
Mitchell A NothemJason R WickmanLaura L GiacomettiJacqueline M BarkerPublished in: Alcoholism, clinical and experimental research (2022)
These data indicate that while ethanol has antiallodynic and antinociceptive effects in male and female mice, the doses and time course of these effects are distinct. Studies investigating the relationship between pain and ethanol exposure in mice should consider sex as a key variable. These data also inform reported sex differences in rodent models of chronic pain and in chronic pain patients.
Keyphrases
- chronic pain
- pain management
- high fat diet induced
- neuropathic pain
- end stage renal disease
- electronic health record
- ejection fraction
- big data
- newly diagnosed
- chronic kidney disease
- body mass index
- physical activity
- type diabetes
- peritoneal dialysis
- adipose tissue
- weight loss
- insulin resistance
- prognostic factors
- spinal cord
- wild type
- machine learning
- spinal cord injury
- weight gain