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Programmable DNA triple-helix molecular switch in biosensing applications: from in homogenous solutions to in living cells.

Pinting TangJing ZhengJianru TangDandan MaWeijian XuJishan LiZhong CaoRonghua Yang
Published in: Chemical communications (Cambridge, England) (2018)
Herein, we demonstrated a new gold nanoparticles (AuNPs)-integrated programmable triple-helix molecular switch (THMS) to realize the biosensing of multiple targets from in homogenous solution to in living cells. The results demonstrated that this proposed programmable THMS could be successfully used for imaging multiple messenger RNA (mRNA) in living cells and it significantly extends the scope of the THMS sensing platform.
Keyphrases
  • living cells
  • single molecule
  • fluorescent probe
  • gold nanoparticles
  • high resolution
  • dna binding
  • label free
  • cell free
  • reduced graphene oxide
  • mass spectrometry
  • single cell
  • fluorescence imaging