Prevalence of and gene regulatory constraints on transcriptional adaptation in single cells.

Ian A MellisMadeline E MelzerNicholas BodkinYogesh Goyal

Published in: Genome biology (2024)

Our integrative approach identifies several putative hits-genes demonstrating possible transcriptional adaptation-to follow-up on experimentally and provides a formal quantitative framework to test and refine models of transcriptional adaptation.

Keyphrases

transcription factor
gene expression
genome wide
induced apoptosis
heat shock
risk factors
cell cycle arrest
high resolution
cell death
oxidative stress
heat stress
bioinformatics analysis