DNA methylation alterations of ADCY5, MICAL2 and PLEKHG2 during the developmental stage of cryptogenic hepatocellular carcinoma.

Satomi MakiuchiYing TianMao FujimotoJunko KuramotoNoboru TsudaHidenori OjimaMasahiro GotohNobuyoshi HiraokaTeruhiko YoshidaYae KanaiEri Arai

Published in: Hepatology research : the official journal of the Japan Society of Hepatology (2023)

U-N-specific DNA hypermethylation of ADCY5 may have significance even from the precancerous stage in liver showing no remarkable histological features. DNA hypomethylation of MICAL2 and PLEKHG2 may determine the clinicopathological features of cryptogenic HCC. This article is protected by copyright. All rights reserved.

Keyphrases

circulating tumor
dna methylation
cell free
single molecule
gene expression
genome wide
nucleic acid
circulating tumor cells
copy number