Neurotrophin-3 promotes peripheral nerve regeneration by maintaining a repair state of Schwann cells after chronic denervation via the TrkC/ERK/c-Jun pathway.

Xiong XuLili SongYueying LiJin GuoShuo HuangShuang DuWeizhen LiRang-Juan CaoShusen Cui

Published in: Journal of translational medicine (2023)

NT-3 promotes peripheral nerve regeneration by maintaining the repair phenotype of Schwann cells after chronic denervation via the TrkC/ERK/c-Jun pathway. It provides a potential target for the clinical treatment of peripheral nerve injury after chronic denervation.

Keyphrases

peripheral nerve
induced apoptosis
signaling pathway
cell cycle arrest
stem cells
pi k akt
cell proliferation
cell death
climate change