Glucosamine and lower mortality and cancer incidence: Selection bias in the observational studies.
Karine SuissaMarie HudsonSamy SuissaPublished in: Pharmacoepidemiology and drug safety (2022)
The observational studies reporting significant reductions in mortality, cancer incidence and other outcomes with glucosamine were affected by selection bias from collider stratification. In the absence of properly conducted observational studies that circumvent this bias by considering "new users", the studies to date cannot support the prescription of this supplement as a preventive measure for mortality, cancer, and other chronic diseases.