Case-only exome variation analysis of severe alcohol dependence using a multivariate hierarchical gene clustering approach.

Amanda Elswick GentryJeffry C AlexanderMohammad Ahangari Roseann E PetersonMichael F MilesJill C BettingerAndrew G DaviesMike GroteweilSilviu A BacanuKenneth S KendlerBrien P RileyBradley Todd Webbnull null

Published in: PloS one (2023)

The proposed method demonstrates a computationally viable and statistically appropriate approach for genetic analysis of case-only data for hypothesized gene sets supported by empirical evidence.

Keyphrases

copy number
genome wide
genome wide identification
dna methylation
early onset
rna seq
single cell
electronic health record
gene expression
deep learning