The insulin signaling pathway is dysregulated in cumulus cells from obese, infertile women with polycystic ovarian syndrome with an absence of clinical insulin resistance.
Mauricio Barbour ChehinRenato FraiettaAline R LorenzonTatiana C S BonettiEduardo L A MottaPublished in: Therapeutic advances in reproductive health (2020)
Together, our findings and the related literature suggest that those alterations may be associated with the worse prognosis of follicular development and oocyte maturation observed in PCOS obese women.
Keyphrases
- polycystic ovary syndrome
- insulin resistance
- adipose tissue
- type diabetes
- metabolic syndrome
- signaling pathway
- weight loss
- high fat diet
- glycemic control
- systematic review
- obese patients
- high fat diet induced
- skeletal muscle
- pi k akt
- bariatric surgery
- case report
- epithelial mesenchymal transition
- induced apoptosis
- cell proliferation