Radiotherapy Advances in Renal Disease-Focus on Renal Ischemic Preconditioning.
Badr KhbouzShiyang GuTiago Pinto CoelhoFrançois LallemandFrançois JouretPublished in: Bioengineering (Basel, Switzerland) (2023)
Ionizing irradiation is widely applied as a fundamental therapeutic treatment in several diseases. Acute kidney injury (AKI) represents a global public health problem with major morbidity and mortality. Renal ischemia/reperfusion (I/R) is the main cause of AKI. I/R injury occurs when blood flow to the kidney is transiently interrupted and then restored. Such an ischemic insult significantly impairs renal function in the short and long terms. Renal ischemic preconditioning (IPC) corresponds to the maneuvers intended to prevent or attenuate the ischemic damage. In murine models, irradiation-induced preconditioning (IP) renders the renal parenchyma resistant to subsequent damage by activating defense pathways involved in oxidative stress, angiogenesis, and inflammation. Before envisioning translational applications in patients, safe irradiation modalities, including timing, dosage, and fractionation, need to be defined.
Keyphrases
- ischemia reperfusion injury
- oxidative stress
- acute kidney injury
- cerebral ischemia
- public health
- blood flow
- radiation induced
- diabetic rats
- end stage renal disease
- cardiac surgery
- dna damage
- chronic kidney disease
- low dose
- ejection fraction
- brain injury
- prognostic factors
- signaling pathway
- radiation therapy
- high glucose
- patient reported
- replacement therapy
- innate immune