Integrated Genomics Reveals Convergent Transcriptomic Networks Underlying Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis.

Rebecca L KuskoJohn F BrothersJohn TedrowKusum PanditLuai HuleihelCatalina PerdomoGang LiuBrenda Juan-GuardelaDaniel KassSherry ZhangMarc LenburgFernando MartinezJohn QuackenbushFrank SciurbaAndrew LimperMark GeraciIvana YangDavid A SchwartzJennifer BeaneAvrum E Spira Naftali Kaminski

Published in: American journal of respiratory and critical care medicine (2017)

Our results suggest convergent transcriptional regulatory hubs in diseases as varied phenotypically as chronic obstructive pulmonary disease and IPF and suggest that these hubs may represent shared key responses of the lung to environmental stresses.

Keyphrases

idiopathic pulmonary fibrosis
chronic obstructive pulmonary disease
single cell
transcription factor
lung function
interstitial lung disease
gene expression
rna seq
human health
heat shock
rheumatoid arthritis