Investigating the effect of sexual behaviour on oropharyngeal cancer risk: a methodological assessment of Mendelian randomization.

Mark GormleyTom DuddingLinda KachuriKimberley BurrowsAmanda H W ChongRichard M MartinSteven J ThomasJessica TyrrellAndrew R NessPaul BrennanMarcus R MunafòMiranda PringStefania BocciaAndrew F OlshanBrenda DiergaardeRayjean J HungGeoffrey LiuEloiza H TajaraPatricia SeverinoTatiana N ToporcovMartin LackoTim WaterboerNicole BrennerGeorge Davey SmithEmma E VincentRebecca C Richmond

Published in: BMC medicine (2022)

Despite using genetic variants strongly related sexual behaviour traits in large-scale GWAS, we found evidence for correlated pleiotropy. This emphasizes a need for multivariable approaches and the triangulation of evidence when performing MR of complex behavioural traits.

Keyphrases

genome wide
mental health
magnetic resonance
magnetic resonance imaging
dna methylation
gene expression
contrast enhanced