Protective effect of suppressor of cytokine signalling 1-based therapy in experimental abdominal aortic aneurysm.

Susana BernalLaura Lopez-SanzLuna Jimenez-CastillaIgnacio PrietoAna MelgarSara La MannaJose Luis Martin-VenturaLuis Miguel Blanco-ColioJesus EgidoCarmen Gomez-Guerrero

Published in: British journal of pharmacology (2020)

This preclinical study demonstrates the therapeutic potential of SOCS1-derived peptide to halt AAA progression by suppressing JAK/STAT-mediated inflammation and aortic dilation. S1 peptide may therefore be a valuable option for the treatment of AAA.

Keyphrases

abdominal aortic aneurysm
oxidative stress
aortic valve
left ventricular
cell therapy
pulmonary artery
stem cells
mesenchymal stem cells
bone marrow